FGF8 (fibroblast growth factor 8 (androgen-induced))
نویسندگان
چکیده
منابع مشابه
Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis
INTRODUCTION Fibroblast growth factor 8 (FGF8) is isolated as an androgen-induced growth factor, and has recently been shown to contribute to limb morphogenesis. The aim of the present study was to clarify the role of FGF8 in animal models of osteoarthritis (OA). METHODS The expression of FGF8 in the partial meniscectomy model of OA in the rabbit knee was examined by immunohistochemistry. The...
متن کاملInduction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar).
Vertebrate heart development is initiated from bilateral lateral plate mesoderm that expresses the Nkx2.5 and GATA4 transcription factors, but the extracellular signals specifying heart precursor gene expression are not known. We describe here that the secreted signaling factor Fgf8 is expressed in and required for development of the zebrafish heart precursors, particularly during initiation of...
متن کاملAndrogen Receptors Interact with the Fibroblast Growth Factor 8 Promoter Region
BODY: Rats selectively bred for high intrinsic aerobic capacity (HCR) are lean, resistant to obesity, and consistently more active than low-capacity runners (LCR), which are more prone to metabolic syndrome and obesity. We have shown that HCR have elevated total daily energy expenditure (EE), primarily due to their activity EE rather than to resting EE. This high activity EE results from height...
متن کاملDifferential Fibroblast Growth Factor 8 (FGF8)-Mediated Autoregulation of Its Cognate Receptors, Fgfr1 and Fgfr3, in Neuronal Cell Lines
Fibroblast growth factors (FGFs) mediate a vast range of CNS developmental processes including neural induction, proliferation, migration, and cell survival. Despite the critical role of FGF signaling for normal CNS development, few reports describe the mechanisms that regulate FGF receptor gene expression in the brain. We tested whether FGF8 could autoregulate two of its cognate receptors, Fgf...
متن کاملSenataxin modulates neurite growth through fibroblast growth factor 8 signalling.
Senataxin is encoded by the SETX gene and is mainly involved in two different neurodegenerative diseases, the dominant juvenile form of amyotrophic lateral sclerosis type 4 and a recessive form of ataxia with oculomotor apraxia type 2. Based on protein homology, senataxin is predicted to be a putative DNA/RNA helicase, while senataxin interactors from patients' lymphoblast cell lines suggest a ...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2012
ISSN: 1768-3262
DOI: 10.4267/2042/46043